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Sebuah ulasan berusia ten tahun, The Two Faces of Capsaicin, merinci percobaan laboratorium dengan hewan pengerat yang menghubungkan capsaicin dengan tanda-tanda kanker di perut dan hati.

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Tinjauan umum lainnya dari tahun 2022, yang menganalisis eleven tinjauan sistematis dan meta-analisis, menyimpulkan bahwa efek kesehatan dari makanan pedas dan masih belum pasti. Bukti-bukti yang mereka dapatkan pun tidak cukup kuat.

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